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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Freshwater algae chemotaxonomy by high-performance liquid chromatographic (HPLC) analysis

Yansong HOU, Wei LIANG, Liping ZHANG, Shuiping CHENG, Feng HE, Zhenbin WU

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 1,   Pages 84-91 doi: 10.1007/s11783-010-0283-1

Abstract: A high-performance liquid chromatographic (HPLC) method based on a reverse-phase C nonpolar column wasBased on the elution order using HPLC, 19 pigments were identified, and they were chlorophyllide , 19A comparison study of cell microscopic counts and accessory pigment analysis indicated that HPLC analysis

Keywords： high-performance liquid chromatographic (HPLC)     algae     pigment     chemotaxonomy    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: Overall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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HPLC determination of glyoxal in aldehyde solution with 3-methyl-2-benzothiazolinone hydrazone

Yamei ZHU, Xiaoli YAO, Shaohui CHEN, Qun CUI, Haiyan WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 117-121 doi: 10.1007/s11705-010-0535-4

Abstract: -methyl-2-benzothiazolinone hydrazone (MBTH) in the Ultraviolet-visible (UV-vis) spectral region, a HPLCGlyoxal was derivatised from MBTH and the derivatives (diazine) were analyzed by HPLC for identificationyellow dye with a maximum molar absorptivity at 401 nm and its retention time was 5.2 min under optimal HPLCThis efficient HPLC technique is also proposed for detecting other dicarbonyl compounds besides glyoxal

Keywords： HPLC     glyoxal     3-methyl-2-benzothiazolinone hydrazone     diazine     dicarbonyl compounds    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: This retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes inMutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencingWe identified at least 1 mutation in 199 of the 259 samples (76.8%), and 2 or more mutations in 31.7%The results showed certain rules in the mutation profiling and concurrence of AML patients, which wasDefining the mutation spectrum and mutation pattern of AML will contribute to the comprehensive assessment

Keywords： leukemia     myeloid     acute     gene     mutation    

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Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 87-90

Abstract: product research should be featured by the application of modern spectroscopic techniques, such as HPLC/MS/MS and HPLC/NMR and so on.

Keywords： research     creating new drug     chemical constituent of Chinese herbal medicine     modem spectroscopic technique     HPLC/MS/MS     HPLC/NMR    

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Experimental study and product analysis of lignocellulosic biomass hydrolysis under extremely low acids

WANG Shurong, LUO Zhongyang, CEN Kefa, ZHUANG Xinshu

Frontiers in Energy 2008, Volume 2, Issue 3,   Pages 268-272 doi: 10.1007/s11708-008-0046-x

Abstract: , sugar component analysis of the products was performed by high performance liquid chromatography (HPLC

Keywords： HPLC     oligosaccharide     lignocellulosic     chromatography     reducing    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: However, it remains uncertain whether NRTIs could induce the hypervariable region (HV) mutations of the DAlterations were compared with the revised Cambridge Reference Sequence (rCRS) to determine mutationIn conclusion, NRTIs could induce mutation of mtDNA HV 2, which might contribute to the development of

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis. Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia (AML). However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainly due to their elusive genetic characteristics. Here, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutations in AML. This expression pattern was coordinated by target repression and promoter hypermethylation. We first reanalyzed a joint AML cohort that consisted of three public cohorts and found that RUNX1 mutations were mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations. Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signature that significantly distinguished the patients with RUNX1 mutations from those with other AML subtypes. Furthermore, we explored the mechanisms underlying this signature from the transcriptional and epigenetic levels. Using chromatin immunoprecipitation sequencing data, we found that RUNX1 target genes tended to be repressed in patients with RUNX1 mutations. Through the integration of DNA methylation array data, we illustrated that hypermethylation on the promoter regions of RUNX1-regulated genes also contributed to dysregulation in RUNX1-mutated AML. This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying mechanisms in AML development.

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm

Gao Shang,Yang Jingyu

Strategic Study of CAE 2006, Volume 8, Issue 11,   Pages 94-98

Abstract: Especially the hybrid particle swarm optimization algorithm derived from across strategy A and mutation

Keywords： particle swarm algorithm     knapsack problem     genetic algorithm     mutation    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: i> deficiency related to PCD in human and mouse models, which suggests that DNAH10 recessive mutation

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract: antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Analysis of two new degradation products of arsenic triglutathione in aqueous solution

Feng ZHAO, Yuchen CHEN, Bin QIAO, Jing WANG, Ping NA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 292-300 doi: 10.1007/s11705-012-1208-2

Abstract: aqueous solution using high-performance liquid chromatography-electrospray ionisation mass spectrometry (HPLC-ESI-MS

Keywords： arsenic triglutathione     glutathione     HPLC-ESI-MS    

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Development of Bioimplants with 2D, 3D, and 4D Additive Manufacturing Materials Review

Guo Liu, Yunhu He, Pengchao Liu, Zhou Chen, Xuliang Chen, Lei Wan, Ying Li, Jian Lu

Engineering 2020, Volume 6, Issue 11,   Pages 1232-1243 doi: 10.1016/j.eng.2020.04.015

Abstract: However, 3D printable materials are still quite limited for the fabrication of bioimplants.In this work, 2D/3D AM materials for bioimplants are reviewed.complex and dynamic biological structures in the human body based on 4D printing hybrid ceramic precursorprinting technology, the development of bioimplants and soft/rigid hybrid biological structures with 2D/3D/4D AM materials can be anticipated.

Keywords： Bioprinting     2D additive manufacturing     3D printing     4D printing     Bioimplants    

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Title Author Date Type Operation

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Freshwater algae chemotaxonomy by high-performance liquid chromatographic (HPLC) analysis

Yansong HOU, Wei LIANG, Liping ZHANG, Shuiping CHENG, Feng HE, Zhenbin WU

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

HPLC determination of glyoxal in aldehyde solution with 3-methyl-2-benzothiazolinone hydrazone

Yamei ZHU, Xiaoli YAO, Shaohui CHEN, Qun CUI, Haiyan WANG

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article

Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Journal Article

Experimental study and product analysis of lignocellulosic biomass hydrolysis under extremely low acids

WANG Shurong, LUO Zhongyang, CEN Kefa, ZHUANG Xinshu

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Journal Article

Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm

Gao Shang,Yang Jingyu

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Analysis of two new degradation products of arsenic triglutathione in aqueous solution

Feng ZHAO, Yuchen CHEN, Bin QIAO, Jing WANG, Ping NA

Journal Article

Development of Bioimplants with 2D, 3D, and 4D Additive Manufacturing Materials

Guo Liu, Yunhu He, Pengchao Liu, Zhou Chen, Xuliang Chen, Lei Wan, Ying Li, Jian Lu

Journal Article